Jan A Gorter Selected Research

Temporal Lobe Epilepsy

1/2022	No persistent effects of intracerebral curcumin administration on seizure progression and neuropathology in the kindling rat model for temporal lobe epilepsy.
10/2021	Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.
1/2021	The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects.
1/2019	Curcumin reduces development of seizurelike events in the hippocampal-entorhinal cortex slice culture model for epileptogenesis.
1/2016	Effects of rapamycin and curcumin treatment on the development of epilepsy after electrically induced status epilepticus in rats.
2/2014	Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy.
12/2012	Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β.
7/2012	Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation.
7/2012	Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.
9/2011	Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy.

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Jan A Gorter Research Topics

Disease

35	Status Epilepticus (Complex Partial Status Epilepticus) 01/2022 - 01/2002
35	Epilepsy (Aura) 10/2021 - 07/2002
24	Temporal Lobe Epilepsy 01/2022 - 01/2002
22	Seizures (Absence Seizure) 01/2022 - 07/2002
9	Inflammation (Inflammations) 01/2019 - 07/2011
4	Encephalitis (Encephalitis, Rasmussen) 01/2016 - 05/2003
4	Neoplasms (Cancer) 12/2012 - 07/2002
4	Focal Cortical Dysplasia 06/2009 - 06/2003
3	Gliosis 01/2022 - 05/2003
3	Hippocampal Sclerosis 10/2021 - 05/2004
3	Tuberous Sclerosis (Bourneville's Disease) 01/2017 - 06/2009
3	Epileptic Syndromes 03/2014 - 07/2002
3	Malformations of Cortical Development 07/2012 - 05/2003
2	Neuroinflammatory Diseases 11/2020 - 03/2014
2	Brain Diseases (Brain Disorder) 12/2017 - 02/2014
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2017 - 07/2012
2	Glioblastoma (Glioblastoma Multiforme) 12/2012 - 05/2003
2	Glioma (Gliomas) 12/2012 - 05/2003
2	Breast Neoplasms (Breast Cancer) 10/2005 - 06/2005
2	Drug Resistant Epilepsy 11/2004 - 09/2003
2	Ganglioglioma 11/2004 - 09/2003
1	Cognitive Dysfunction 01/2021
1	Intellectual Disability (Idiocy) 01/2017
1	Autistic Disorder (Autism) 01/2017
1	Body Weight (Weight, Body) 01/2016
1	Sepsis (Septicemia) 04/2013
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 07/2012
1	Polyhydramnios 07/2012
1	Spasm (Spasms) 07/2012
1	Infantile Spasms (West Syndrome) 07/2012
1	Multiple Hamartoma Syndrome (Cowden's Disease) 07/2012
1	Megalencephaly 07/2012
1	Nervous System Diseases (Neurological Disorders) 01/2012
1	Central Nervous System Diseases (CNS Diseases) 09/2009

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2017 - 01/2002
12	Pharmaceutical PreparationsIBA 01/2022 - 07/2002
12	Kainic Acid (Kainate)IBA 01/2021 - 07/2002
7	Sirolimus (Rapamycin)FDA Link 01/2019 - 07/2012
7	Messenger RNA (mRNA)IBA 11/2017 - 07/2002
6	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 09/2010 - 07/2002
4	TOR Serine-Threonine KinasesIBA 01/2019 - 07/2012
4	Biomarkers (Surrogate Marker)IBA 11/2018 - 04/2013
4	Anticonvulsants (Antiepileptic Drugs)IBA 12/2017 - 07/2002
4	MicroRNAs (MicroRNA)IBA 12/2017 - 01/2012
4	Phenytoin (Dilantin)FDA LinkGeneric 02/2010 - 07/2002
3	CurcuminIBA 01/2022 - 01/2016
3	IronIBA 10/2021 - 09/2005
3	CytokinesIBA 07/2018 - 12/2012
3	trans-sodium crocetinate (crocetin)IBA 01/2017 - 06/2009
3	Sodium Channels (Sodium Channel)IBA 09/2013 - 07/2002
3	Levetiracetam (Keppra)FDA LinkGeneric 03/2010 - 07/2008
3	major vault proteinIBA 12/2004 - 09/2003
2	AntioxidantsIBA 01/2022 - 10/2021
2	Matrix Metalloproteinase InhibitorsIBA 01/2021 - 07/2018
2	Matrix Metalloproteinases (MMPs)IBA 01/2021 - 07/2018
2	Pilocarpine (Ocusert)FDA LinkGeneric 01/2017 - 09/2009
2	RNA (Ribonucleic Acid)IBA 01/2017 - 10/2006
2	InterleukinsIBA 04/2013 - 03/2005
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 09/2010 - 02/2010
2	Multidrug Resistance-Associated ProteinsIBA 10/2005 - 05/2004
2	CalciumIBA 10/2004 - 08/2002
2	PlasticsIBA 05/2003 - 01/2002
2	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 05/2003 - 01/2002
1	Metalloproteases (Metalloproteinases)IBA 01/2021
1	AlbuminsIBA 11/2020
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2017
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017
1	Therapeutic UsesIBA 01/2016
1	Contrast MediaIBA 01/2016
1	gadobutrolIBA 01/2016
1	Methylprednisolone FDA LinkGeneric 03/2014
1	GlucocorticoidsIBA 03/2014
1	Glutathione (Reduced Glutathione)IBA 03/2014
1	C-Reactive ProteinIBA 04/2013
1	EnzymesIBA 04/2013
1	ImmunosorbentsIBA 04/2013
1	LipopolysaccharidesIBA 04/2013
1	Interleukin-6 (Interleukin 6)IBA 04/2013
1	Interleukin-1 (Interleukin 1)IBA 12/2012
1	PotassiumIBA 12/2012
1	Kcnj10 (channel)IBA 12/2012
1	Neurofibromin 1 (Neurofibromin)IBA 07/2012
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 07/2012
1	Immunosuppressive Agents (Immunosuppressants)IBA 07/2012
1	Phosphotransferases (Kinase)IBA 07/2012
1	TensinsIBA 07/2012
1	Adenosine (Adenocard)FDA LinkGeneric 09/2011
1	Adenosine KinaseIBA 09/2011
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 07/2011
1	Atorvastatin (Lipitor)FDA Link 07/2011
1	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 02/2010
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 02/2010
1	4- (5- (4- chlorophenyl)- 3- (trifluoromethyl)- 1H- pyrazol- 1- yl)benzenesulfonamideIBA 02/2010
1	Glutamic Acid (Glutamate)FDA Link 02/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2008
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 06/2008
1	tariquidar (XR9576)IBA 04/2006

Therapy/Procedure

2	Therapeutics 07/2018 - 02/2014
2	Injections 01/2005 - 06/2003
1	Lasers (Laser) 01/2017